Bharadwaj Arpita S, Agrawal Devendra K
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178, USA.
Immunol Res. 2007;37(1):79-96. doi: 10.1007/BF02686091.
Dendritic cells (DCs) are potent antigen-presenting cells that guard all parts of the body. They have the unique ability to prime T cells and generate primary immune responses. Their journey beginning with the development from precursor cells and ending with their death is controlled by a group of transcription factors. Some of the transcription factors like PU.1 are involved in more than one stage of DC life. Other transcription factors including Ikaros and JAK3 are involved in the development of more than one cell type. For a long time, the cellular and molecular mechanisms underlying the development, differentiation, maturation, and other stages of DC life were not well understood. However, in recent years novel information has been published by many researchers to better understand the molecular mechanisms of the development and function of DCs in immunological diseases such as asthma, cancer, autoimmunity, and transplantation. This review will discuss the various transcription factors and signaling pathways involved in each stage of the life cycle of DCs.
树突状细胞（DCs）是强大的抗原呈递细胞，守护着身体的各个部位。它们具有启动T细胞并产生初级免疫反应的独特能力。从祖细胞发育开始到死亡的整个过程受一组转录因子的调控。一些转录因子，如PU.1，参与DC生命周期的多个阶段。其他转录因子，包括Ikaros和JAK3，参与多种细胞类型的发育。长期以来，DC发育、分化、成熟及其他生命阶段的细胞和分子机制一直未被充分理解。然而，近年来许多研究人员发表了新的信息，以更好地了解DC在哮喘、癌症、自身免疫和移植等免疫性疾病中的发育和功能的分子机制。本综述将讨论DC生命周期各阶段涉及的各种转录因子和信号通路。
