Ceredig Rhodri, Rolink Antonius G, Brown Geoffrey
Regenerative Medicine Institute, National Centre for Biomedical Engineering Science, Department of Physiology, National University of Ireland, Galway, Ireland.
Nat Rev Immunol. 2009 Apr;9(4):293-300. doi: 10.1038/nri2525.
Many models of haematopoiesis dictate that haematopoietic stem cells make an early and irrevocable choice between lymphoid and myeloid cell fates. However, recent data show that intermediate progenitors have both lymphoid and myeloid potential, thereby refuting early theories and leading to a lack of consensus in the field. In this Opinion article we present a simple pairwise relationships model of cell fate determination that does not depend on the underlying developmental branch points that in other models dictate a preferred route (or routes) to a particular cell fate.
许多造血模型表明，造血干细胞在淋巴样和髓样细胞命运之间做出早期且不可逆转的选择。然而，最近的数据显示，中间祖细胞具有淋巴样和髓样潜能，从而驳斥了早期理论，并导致该领域缺乏共识。在这篇观点文章中，我们提出了一个简单的细胞命运决定成对关系模型，该模型不依赖于其他模型中决定特定细胞命运的首选途径（或多条途径）的潜在发育分支点。
