Ellis J S, Averley P A, Preshaw P M, Steele J G, Seymour R A, Thomason J M
School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, UK.
Br Dent J. 2007 May 12;202(9):543-4. doi: 10.1038/bdj.2007.373.
There is considerable debate over the relationship between periodontal and cardiovascular disease. It has been postulated that inflammatory mediators prevalent in periodontal disease may impact on atheroma formation and the thrombotic process. In cross-sectional, observational studies, periodontitis is associated with elevated C-reactive protein (CRP), hyperfibrinogenaemia and moderate leukocytosis. CRP levels have also been shown to decrease following periodontal therapy. CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events.
关于牙周病与心血管疾病之间的关系存在大量争议。据推测，牙周病中普遍存在的炎症介质可能会影响动脉粥样硬化的形成和血栓形成过程。在横断面观察性研究中，牙周炎与C反应蛋白（CRP）升高、高纤维蛋白原血症和中度白细胞增多有关。牙周治疗后CRP水平也已显示会下降。CRP是感染和/或炎症急性期反应的可靠标志物，也是未来冠状动脉事件的有力预测指标。
