Chiu Hui-Fen, Tsai Shang-Shyue, Yang Chun-Yuh
Department of Pharmacology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
J Toxicol Environ Health A. 2007 Jun;70(12):1000-4. doi: 10.1080/15287390601171801.
The relationship between nitrate levels in drinking water and bladder cancer development is controversial. A matched cancer case-control with nitrate ecology study was used to investigate the association between bladder cancer mortality occurrence and nitrate exposure from Taiwan drinking water. All bladder cancer deaths of Taiwan residents from 1999 through 2003 were obtained from the Bureau of Vital Statistics of the Taiwan Provincial Department of Health. Controls were deaths from other causes and were pair-matched to the cases by gender, year of birth,and year of death. Each matched control was selected randomly from the set of possible controls for each cancer case. Data on nitrate-nitrogen (NO3-N) levels in drinking water throughout Taiwan were collected from Taiwan Water Supply Corporation (TWSC). The municipality of residence for cancer cases and controls was assumed to be the source of the subject's nitrate exposure via drinking water. The adjusted odds ratios for bladder cancer death for those with high nitrate levels in their drinking water were 1.76 (1.28-2.42) and 1.96 (1.41-2.72) as compared to the lowest tertile. The results of the present study show that there was a significant positive relationship between the levels of nitrate in drinking water and risk of death from bladder cancer.
饮用水中硝酸盐水平与膀胱癌发展之间的关系存在争议。一项将癌症病例与硝酸盐生态学研究相匹配的对照研究，用于调查台湾饮用水中膀胱癌死亡率与硝酸盐暴露之间的关联。1999年至2003年台湾居民所有膀胱癌死亡病例来自台湾省卫生厅人口动态统计处。对照为其他原因导致的死亡病例，并按性别、出生年份和死亡年份与病例进行配对。每个匹配的对照从每个癌症病例的可能对照集中随机选取。台湾各地饮用水中硝酸盐氮（NO3-N）水平的数据收集自台湾自来水公司（TWSC）。假设癌症病例和对照的居住市为受试者通过饮用水接触硝酸盐的来源。与最低三分位数相比，饮用水中硝酸盐水平高的人群膀胱癌死亡的调整优势比分别为1.76（1.28 - 2.42）和1.96（1.41 - 2.72）。本研究结果表明，饮用水中硝酸盐水平与膀胱癌死亡风险之间存在显著的正相关关系。
