Xu Jiaxi
State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, People's Republic of China.
Beilstein J Org Chem. 2020 Jun 22;16:1357-1410. doi: 10.3762/bjoc.16.116. eCollection 2020.
Thietanes are important aliphatic four-membered thiaheterocycles that are found in the pharmaceutical core and structural motifs of some biological compounds. They are also useful intermediates in organic synthesis. Various synthetic methods of thietanes have been developed, including inter- and intramolecular nucleophilic thioetherifications, photochemical [2 + 2] cycloadditions, ring expansions and contractions, nucleophilic cyclizations, and some miscellaneous methods. The recently developed methods provide some new strategies for the efficient preparation of thietanes and their derivatives. This review focuses on the synthetic methods to construct thietane backbones developed during 1966 to 2019.
硫杂环丁烷是重要的脂肪族四元硫杂环化合物，存在于某些生物化合物的药物核心结构和结构基序中。它们也是有机合成中有用的中间体。已开发出多种合成硫杂环丁烷的方法，包括分子间和分子内亲核硫醚化反应、光化学[2 + 2]环加成反应、环的扩大和收缩、亲核环化反应以及一些其他方法。最近开发的方法为高效制备硫杂环丁烷及其衍生物提供了一些新策略。本综述重点关注1966年至2019年间开发的构建硫杂环丁烷骨架的合成方法。
