文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

McIntyre I M, Oxenkrug G F

Department of Psychiatry, University of Melbourne, Vic., Australia.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(4):561-6. doi: 10.1016/0278-5846(91)90031-u.

This paper describes the effect of the serotonin precursor 5-hydroxytryptophan (5-HTP) on pineal melatonin synthesis young and old rats. 2. 5-HTP itself increased pineal melatonin levels in old rats but did not change melatonin concentrations in young rats kept under 12 hr/12 hr light/dark conditions. 3. After continuous exposure to light for 72 hrs, 5-HTP induced a significant increase in melatonin levels in young rats but did not change the 5-HTP effect on melatonin in old animals. 4. These results are discussed in consideration of previous reports of altered beta-receptor up-regulation by light in old animals, and suggest that the age-related decrease in melatonin synthesis is not entirely related to changes of the enzymatic machine for melatonin synthesis.

本文描述了血清素前体5-羟色氨酸（5-HTP）对幼年和老年大鼠松果体褪黑素合成的影响。2. 5-HTP本身可提高老年大鼠松果体褪黑素水平，但对处于12小时光照/12小时黑暗条件下的幼年大鼠的褪黑素浓度没有影响。3. 在连续暴露于光照72小时后，5-HTP可使幼年大鼠的褪黑素水平显著升高，但对老年动物褪黑素的影响没有改变。4. 结合之前关于老年动物光照引起β受体上调改变的报道对这些结果进行了讨论，结果表明，与年龄相关的褪黑素合成减少并不完全与褪黑素合成酶机制的变化有关。

McIntyre I M, Oxenkrug G F

Department of Psychiatry, University of Melbourne, Vic., Australia.

Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(4):561-6. doi: 10.1016/0278-5846(91)90031-u.

This paper describes the effect of the serotonin precursor 5-hydroxytryptophan (5-HTP) on pineal melatonin synthesis young and old rats. 2. 5-HTP itself increased pineal melatonin levels in old rats but did not change melatonin concentrations in young rats kept under 12 hr/12 hr light/dark conditions. 3. After continuous exposure to light for 72 hrs, 5-HTP induced a significant increase in melatonin levels in young rats but did not change the 5-HTP effect on melatonin in old animals. 4. These results are discussed in consideration of previous reports of altered beta-receptor up-regulation by light in old animals, and suggest that the age-related decrease in melatonin synthesis is not entirely related to changes of the enzymatic machine for melatonin synthesis.

本文描述了血清素前体5-羟色氨酸（5-HTP）对幼年和老年大鼠松果体褪黑素合成的影响。2. 5-HTP本身可提高老年大鼠松果体褪黑素水平，但对处于12小时光照/12小时黑暗条件下的幼年大鼠的褪黑素浓度没有影响。3. 在连续暴露于光照72小时后，5-HTP可使幼年大鼠的褪黑素水平显著升高，但对老年动物褪黑素的影响没有改变。4. 结合之前关于老年动物光照引起β受体上调改变的报道对这些结果进行了讨论，结果表明，与年龄相关的褪黑素合成减少并不完全与褪黑素合成酶机制的变化有关。