Cavallo A, Richards G E, Meyer W J, Waldrop R D
Department of Pediatrics, University of Texas Medical Branch, Galveston.
Horm Res. 1987;27(2):69-73. doi: 10.1159/000180790.
We tested the hypothesis that acute 5-hydroxytryptophan (5-HTP) administration would cause an increase in concentrations of plasma melatonin to levels observed during the spontaneous nocturnal melatonin surge. We administered 5-HTP orally (5-12 mg/kg) to 10 healthy children and 5 healthy adults, and measured melatonin concentrations in plasma samples obtained every 30 min for 3-6 h. There was no appreciable increase in melatonin after 5-HTP stimulation, even though a melatonin increase has been reported in sheep treated with 5-HTP.
急性给予5-羟色氨酸（5-HTP）会使血浆褪黑素浓度升高至自发夜间褪黑素激增期间所观察到的水平。我们对10名健康儿童和5名健康成人口服给予5-HTP（5 - 12毫克/千克），并在3 - 6小时内每隔30分钟采集血浆样本，测量其中的褪黑素浓度。尽管已有报道称用5-HTP处理的绵羊褪黑素会增加，但在5-HTP刺激后，褪黑素并没有明显增加。
