Tunik E, Rice N J, Hamilton A, Grafton S T
Department of Physical Therapy, Steinhardt School of Education, New York University, NY, USA.
Neuroimage. 2007;36 Suppl 2(Suppl 2):T77-86. doi: 10.1016/j.neuroimage.2007.03.026. Epub 2007 Mar 28.
The fronto-parietal network has been implicated in the processing of multisensory information for motor control. Recent methodological advances with both fMRI and TMS provide the opportunity to dissect the functionality of this extensive network in humans and may identify distinct contributions of local neural populations within this circuit that are not only related to motor planning, but to goal oriented behavior as a whole. Herein, we review and make parallels between experiments in monkeys and humans on a broad array of motor as well as non-motor tasks in order to characterize the specific contribution of a region in the parietal lobe, the anterior intraparietal sulcus (aIPS). The intent of this article is to review: (1) the historical perspectives on the parietal lobe, particularly the aIPS; (2) extend and update these perspectives based on recent empirical data; and (3) discuss the potential implications of the revised functionality of the aIPS in relationship to complex goal oriented behavior and social interaction. Our contention is that aIPS is a critical node within a network involved in the higher order dynamic control of action, including representation of intended action goals. These findings may be important not only for guiding the design of future experiments investigating related issues but may also have valuable utility in other fields, such social neuroscience and biomedical engineering.
额顶叶网络与用于运动控制的多感官信息处理有关。功能磁共振成像（fMRI）和经颅磁刺激（TMS）最近的方法学进展为剖析人类这个广泛网络的功能提供了机会，并且可能确定该回路中局部神经群体的不同贡献，这些贡献不仅与运动规划有关，而且与整体的目标导向行为有关。在此，我们回顾并比较了猴子和人类在一系列广泛的运动以及非运动任务上的实验，以便描述顶叶中一个区域——顶内沟前部（aIPS）的具体贡献。本文的目的是回顾：（1）关于顶叶，特别是aIPS的历史观点；（2）基于最近的实证数据扩展和更新这些观点；（3）讨论aIPS功能修订版与复杂目标导向行为和社会互动相关的潜在影响。我们的论点是，aIPS是一个网络中的关键节点，该网络参与动作的高阶动态控制，包括预期动作目标的表征。这些发现可能不仅对指导未来研究相关问题的实验设计很重要，而且在其他领域，如社会神经科学和生物医学工程中也可能有宝贵的用途。
