Sokolsky-Papkov Marina, Agashi Kapil, Olaye Andrew, Shakesheff Kevin, Domb Abraham J
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Adv Drug Deliv Rev. 2007 May 30;59(4-5):187-206. doi: 10.1016/j.addr.2007.04.001. Epub 2007 Apr 27.
Growing demand for tissues and organs for transplantation and the inability to meet this need using by autogeneic (from the host) or allogeneic (from the same species) sources has led to the rapid development of tissue engineering as an alternative. Tissue engineering aims to replace or facilitate the regrowth of damaged or diseased tissue by applying a combination of biomaterials, cells and bioactive molecules. This review focuses on synthetic polymers that have been used for tissue growth scaffold fabrication and their applications in both cell and extracellular matrix support and controlling the release of cell growth and differentiation supporting drugs.
对移植用组织和器官的需求不断增长，而利用自体（来自宿主）或同种异体（来自同一物种）来源无法满足这一需求，这导致了组织工程作为一种替代方法的迅速发展。组织工程旨在通过应用生物材料、细胞和生物活性分子的组合来替代或促进受损或患病组织的再生。本综述重点关注用于组织生长支架制造的合成聚合物及其在细胞和细胞外基质支持以及控制细胞生长和分化支持药物释放方面的应用。
