Lee Terence K, Poon Ronnie T P, Man Kwan, Guan Xin-Yuan, Ma Stephanie, Liu Xiao Bing, Myers Jeffrey N, Yuen Anthony P W
Department of Surgery, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, China.
Cancer Lett. 2007 Sep 8;254(2):308-15. doi: 10.1016/j.canlet.2007.03.017. Epub 2007 May 11.
Oral squamous cell carcinoma (OSCC) is associated with a high potential of tumor recurrence and metastasis, leading to poor prognosis. Cell motility is an important factor in the progression and metastasis of cancers. Recently, Fascin has been linked to tumor progression by induction of cell motility. However, the precise roles of Fascin in OSCC have not been elucidated clearly. The aim of this study was to analyze the roles of Fascin in OSCC progression using OSCC clinical samples. We demonstrated that Fascin over-expression was found in OSCC clinical samples and its expression was significantly associated with nodal metastasis (p=0.027), tumor recurrence (p<0.001) and poor patients' overall survival (p=0.013). Consistently, Fascin proteins were detected in all OSCC cell lines with the expression level corresponding to the invasion ability. To specifically investigate the mechanism of Fascin in OSCC, we examined the E-cadherin expression in the same set of OSCC specimens. Fascin was negatively correlated with E-cadherin expression (p=0.018, r=-0.513). In conclusion, our findings suggested that Fascin over-expression might enhance OSCC aggressiveness, possibly by interacting with E-cadherin expression.
口腔鳞状细胞癌（OSCC）具有较高的肿瘤复发和转移潜能，导致预后不良。细胞运动性是癌症进展和转移的一个重要因素。最近，Fascin通过诱导细胞运动性与肿瘤进展相关联。然而，Fascin在OSCC中的具体作用尚未明确阐明。本研究的目的是使用OSCC临床样本分析Fascin在OSCC进展中的作用。我们证明在OSCC临床样本中发现Fascin过表达，其表达与淋巴结转移（p = 0.027）、肿瘤复发（p < 0.001）及患者总生存期较差（p = 0.013）显著相关。同样，在所有OSCC细胞系中均检测到Fascin蛋白，其表达水平与侵袭能力相对应。为了具体研究Fascin在OSCC中的机制，我们检测了同一组OSCC标本中E-钙黏蛋白的表达。Fascin与E-钙黏蛋白表达呈负相关（p = 0.018，r = -0.513）。总之，我们的研究结果表明，Fascin过表达可能通过与E-钙黏蛋白表达相互作用增强OSCC的侵袭性。
