Zhang Naibin, Gao Yankun, Bian Qiang, Wang Qianqian, Shi Ying, Zhao Zhankui, Yu Honglian
Department of biochemistry, Jining Medical University, Jining, China.
Collaborative Innovation Center, Jining Medical University, Jining, China.
Front Oncol. 2022 Aug 11;12:948110. doi: 10.3389/fonc.2022.948110. eCollection 2022.
Human cancer statistics report that respiratory related cancers such as lung, laryngeal, oral and nasopharyngeal cancers account for a large proportion of tumors, and tumor metastasis remains the major reason for patient death. The metastasis of tumor cells requires actin cytoskeleton remodeling, in which fascin-1 plays an important role. Fascin-1 can cross-link F-actin microfilaments into bundles and form finger-like cell protrusions. Some studies have shown that fascin-1 is overexpressed in human tumors and is associated with tumor growth, migration and invasion. The role of fascin-1 in respiratory related cancers is not very clear. The main purpose of this study was to provide an updated literature review on the role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers. These studies suggested that fascin-1 can serve as an emerging biomarker and potential therapeutic target, and has attracted widespread attention.
人类癌症统计报告显示，肺癌、喉癌、口腔癌和鼻咽癌等呼吸道相关癌症在肿瘤中占很大比例，而肿瘤转移仍然是患者死亡的主要原因。肿瘤细胞的转移需要肌动蛋白细胞骨架重塑，其中fascin-1发挥着重要作用。Fascin-1可以将F-肌动蛋白微丝交联成束，并形成指状细胞突起。一些研究表明，fascin-1在人类肿瘤中过度表达，并与肿瘤生长、迁移和侵袭有关。Fascin-1在呼吸道相关癌症中的作用尚不完全清楚。本研究的主要目的是提供一篇关于fascin-1在呼吸道相关癌症的发病机制、诊断和治疗中作用的最新文献综述。这些研究表明，fascin-1可以作为一种新兴的生物标志物和潜在的治疗靶点，已引起广泛关注。
