Lefrère Jean-Jacques
Institut national de la transfusion sanguine, Paris, France.
Transfus Clin Biol. 2007 May;14(1):25-34. doi: 10.1016/j.tracli.2007.04.007. Epub 2007 May 11.
Since the publication of observations of variant Creutzfeld-Jacob disease (vCJD) having occurred in the UK due to transfusion of infected packed red cells, the risk of vCJD transmission by blood transfusion is established. In France, no such case has yet been reported, but among the French vCJD cases observed, three individuals, having entered the disease in 2004, are past blood donors. Thus, some individuals transfused in their past are at risk of developing a vCJD. The lack of available assay prevents the diagnosis of the infection in these recipients and the implementation of a specific screening of blood donations. In the UK and in France, several measures to ensure transfusion safety have been applied to reduce the risk of contamination by the variant.
自从有观察报告称英国因输注受感染的红细胞成分而出现变异型克雅氏病（vCJD）以来，输血传播vCJD的风险已得到确认。在法国，尚未报告过此类病例，但在观察到的法国vCJD病例中，有三名于2004年发病的患者曾是献血者。因此，一些过去接受过输血的人有患vCJD的风险。由于缺乏可用的检测方法，无法对这些受血者的感染情况进行诊断，也无法对献血进行特异性筛查。在英国和法国，已经采取了多项措施来确保输血安全，以降低变异型病原体污染的风险。
