Bastard J P, Vandernotte J M, Faraj M, Karelis A D, Messier L, Malita F M, Garrel D, Prud'homme D, Rabasa-Lhoret R
Service de Biochimie et Hormonologie, Hôpital Tenon, APHP, 75020 Paris, France.
Diabetes Metab. 2007 Sep;33(4):261-8. doi: 10.1016/j.diabet.2007.02.004. Epub 2007 May 11.
The purpose of this study was to compare assessment of insulin sensitivity from hyperinsulinemic euglycaemic (HIEG) clamp with indexes derived from fasting and oral glucose tolerance test (OGTT).
Cross-sectional study with 107 sedentary non-diabetic overweight and obese postmenopausal (BMI=32.4+/-0.4 kg/m(2)) women undergoing both HIEG clamp and OGTT. Pairs of data were analyzed using Pearson correlation and Bland-Altman graphs analysis. Comparison between correlations was made using the method reported by Zar.
All the indexes derived from either the OGTT or surrogate indexes were highly correlated with all the clamp-derived formulas (P<0.0001). However, HOMA and QUICKI were generally less correlated than OGTT-derived indexes. Analogically to QUICKI, we calculated a new formula derived from the OGTT measurements of glucose and insulin named simple index assessing insulin sensitivity (SI(is)OGTT)=1/[log(sum glucose t(0-30-90-120)) (mmol/l)+log(sum insulin t(0-30-90-120)) (microUI/ml)]. By using this formula, we found high significant correlations (r's=0.61-0.65; P<0.0001) with the clamp results. Moreover, the correlations of SI(is)OGTT with the clamp data were higher than for other previously published indexes.
In that large group of non-diabetic overweight and obese postmenopausal women insulin sensitivity index derived from OGTT provided more accurate information than fasting based formula. We propose a new simple index for the assessment of insulin sensitivity from the OGTT data (SI(is)OGTT). The advantage of this new formula over all previously published OGTT-derived indexes of insulin sensitivity is that it is 1) easy to calculate 2) better correlated than other indexes of insulin sensitivity and 3) not affected by the way clamp results are expressed. Further studies are needed to validate SI(is)OGTT index in other populations.
本研究旨在比较通过高胰岛素正葡萄糖钳夹技术（HIEG）评估的胰岛素敏感性与源自空腹及口服葡萄糖耐量试验（OGTT）的指标。
对107名久坐不动的非糖尿病超重及肥胖绝经后女性（BMI = 32.4±0.4 kg/m²）进行横断面研究，这些女性同时接受了HIEG钳夹技术和OGTT检测。采用Pearson相关性分析和Bland - Altman图分析对成对数据进行分析。使用Zar报告的方法对相关性进行比较。
源自OGTT或替代指标的所有指标与所有源自钳夹技术的公式均高度相关（P < 0.0001）。然而，稳态模型评估法（HOMA）和定量胰岛素敏感性检查指数（QUICKI）通常比源自OGTT的指标相关性更低。类似于QUICKI，我们从葡萄糖和胰岛素的OGTT测量值计算出一个新公式，称为评估胰岛素敏感性的简单指数（SI(is)OGTT）= 1 / [log(葡萄糖总和t(0 - 30 - 90 - 120))（mmol/L）+ log(胰岛素总和t(0 - 30 - 90 - 120))（微国际单位/毫升）]。通过使用该公式，我们发现其与钳夹结果具有高度显著的相关性（r值 = 0.61 - 0.65；P < 0.0001）。此外，SI(is)OGTT与钳夹数据的相关性高于其他先前发表的指标。
在那一大组非糖尿病超重及肥胖绝经后女性中，源自OGTT的胰岛素敏感性指数比基于空腹的公式提供了更准确的信息。我们提出了一个用于从OGTT数据评估胰岛素敏感性的新简单指数（SI(is)OGTT）。这个新公式相对于所有先前发表的源自OGTT的胰岛素敏感性指标的优势在于：1）易于计算；2）与其他胰岛素敏感性指标的相关性更好；3）不受钳夹结果表达方式的影响。需要进一步研究以在其他人群中验证SI(is)OGTT指数。
