Kenton Kimberly, Simmons Jennifer, FitzGerald Mary Pat, Lowenstein Lior, Brubaker Linda
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Urology, Loyola University Medical Center, Chicago, Illinois, USA.
J Urol. 2007 Jul;178(1):189-92; discussion 192. doi: 10.1016/j.juro.2007.03.032. Epub 2007 May 17.
Given increased evidence of sensory dysfunction in lower urinary tract pathology, we determined normative current perception threshold values in the lower urinary tract of asymptomatic women.
After receiving institutional review board approval women without lower urinary tract symptoms underwent current perception threshold testing of the urethra and bladder using a Neurometer constant current stimulator. Current perception threshold values were determined at 3 frequencies, including 2,000 Hz (corresponding to A-beta fibers), 250 Hz (corresponding to A-delta fibers) and 5 Hz (corresponding to C fibers).
A total of 48 women with a mean age of 38 years (range 23 to 67) underwent current perception threshold testing. Normative values were established for the urethra and bladder at 2,000, 250 and 5 Hz. Median urethral current perception thresholds at 2,000, 250 and 5 Hz were 1.2 (IQR 0.76-1.5), 0.45 (IQR 0.33-0.56) and 0.11 mA (IQR 0.07-0.24), respectively. Median bladder current perception thresholds at 2,000, 250 and 5 Hz were 4.1 (IQR 2.0-6.3), 2.3 (IQR 0.87-5.5) and 1.4 mA (IQR 0.22-2.9), respectively. Urethral and bladder current perception thresholds increased significantly with subject age at all 3 frequencies (p<0.0005). Prior pelvic surgery was associated with an increased bladder current perception threshold at all 3 frequencies (p<0.005) but not with the urethral current perception threshold.
We report urethral and bladder current perception thresholds for a large sample of asymptomatic women. These reference values may help elucidate changes in afferent nerve function in women with lower urinary tract dysfunction.
鉴于下尿路病理中感觉功能障碍的证据增多，我们确定了无症状女性下尿路的正常电流感觉阈值。
在获得机构审查委员会批准后，对无下尿路症状的女性使用神经测量仪恒流刺激器进行尿道和膀胱的电流感觉阈值测试。在3个频率下确定电流感觉阈值，包括2000Hz（对应A-β纤维）、250Hz（对应A-δ纤维）和5Hz（对应C纤维）。
共有48名平均年龄为38岁（范围23至67岁）的女性接受了电流感觉阈值测试。确定了尿道和膀胱在2000Hz、250Hz和5Hz时的正常数值。在2000Hz、250Hz和5Hz时，尿道电流感觉阈值的中位数分别为1.2（四分位间距0.76 - 1.5）、0.45（四分位间距0.33 - 0.56）和0.11mA（四分位间距0.07 - 0.24）。在2000Hz、250Hz和5Hz时，膀胱电流感觉阈值的中位数分别为4.1（四分位间距2.0 - 6.3）、2.3（四分位间距0.87 - 5.5）和1.4mA（四分位间距0.22 - 2.9）。在所有3个频率下，尿道和膀胱电流感觉阈值均随受试者年龄显著增加（p<0.0005）。既往盆腔手术与所有3个频率下膀胱电流感觉阈值升高相关（p<0.005），但与尿道电流感觉阈值无关。
我们报告了大量无症状女性的尿道和膀胱电流感觉阈值。这些参考值可能有助于阐明下尿路功能障碍女性传入神经功能的变化。
