离子载体A23187所示钙和镁在人中性粒细胞某些功能中的作用
Role of Ca2+ and Mg2+ in some human neutrophil functions as indicated by ionophore A23187.
作者信息
Estensen R D, Reusch M E, Epstein M L, Hill H R
出版信息
Infect Immun. 1976 Jan;13(1):146-51. doi: 10.1128/iai.13.1.146-151.1976.
Abstract
Studies with the divalent cation ionophore A23187 suggest that both Ca2+ and Mg2+ ion influx play a role in human peripheral blood neutrophil function. Degranulation of neutrophils occurred at ionophore concentrations of 10(-5) M and was Ca2+ but not Mg2+ dependent. Modulation of neutrophil chemotaxis was enhanced optimally by 10(-7) M ionophore and was both Ca2+ and Mg2+ dependent. Concentrations of ionophore as low as 10(-12) M seemed to sensitize the cells to a concentration of phorbol myristate acetate which by itself was not chemotactic. These findings also indicate that factors other than Ca2+ or increases in cyclic nucleotides are important to initiation and modulation of neutrophil function.
摘要
对二价阳离子离子载体A23187的研究表明，Ca2+和Mg2+离子内流在人类外周血中性粒细胞功能中均起作用。在离子载体浓度为10(-5) M时中性粒细胞发生脱颗粒，且依赖Ca2+而非Mg2+。10(-7) M离子载体可最佳地增强中性粒细胞趋化性的调节，且同时依赖Ca2+和Mg2+。低至10(-12) M的离子载体浓度似乎使细胞对佛波酯肉豆蔻酸酯乙酸盐浓度敏感，而该物质本身并无趋化作用。这些发现还表明，除Ca2+或环核苷酸增加以外的因素对中性粒细胞功能的启动和调节也很重要。
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