合并多种慢性病毒性肝炎的HIV感染患者丙型肝炎病毒的清除情况

Clearance of hepatitis C virus in HIV-infected patients with multiple chronic viral hepatitis.

作者信息

Martín-Carbonero L, Barreiro P, Jiménez-Galán G, García-Berriguete R, Núñez M, Ríos P, González-Lahoz J, Soriano V

机构信息

Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain.

出版信息

J Viral Hepat. 2007 Jun;14(6):392-5. doi: 10.1111/j.1365-2893.2006.00839.x.

DOI:10.1111/j.1365-2893.2006.00839.x

PMID:17501759

Abstract

Viral interferences between hepatitis C (HCV) and hepatitis B (HBV) viruses were investigated in a case-control study conducted in 107 human immunodeficiency virus (HIV)-infected patients with HCV antibodies. Overall, 15 (68%) of 22 hepatitis B surface antigen (HBsAg)-positive patients had negative serum HCV-RNA while it occurred in only nine (10%) of 85 HBsAg-negative counterparts (P = 0.02). After adjusting for age, antiretroviral therapy, plasma HIV-RNA and CD4 counts, being HBsAg-positive was strongly associated with having negative serum HCV-RNA (odds ratio: 23; 95% confidence interval: 6-59; P < 0.001). Thus, HBV may favour the elimination of HCV in HIV-infected patients, which may influence liver disease and therapeutic decisions.

摘要

在一项针对107名感染人类免疫缺陷病毒（HIV）且具有丙型肝炎病毒（HCV）抗体的患者进行的病例对照研究中，对丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）之间的病毒干扰情况进行了调查。总体而言，22名乙型肝炎表面抗原（HBsAg）阳性患者中有15名（68%）血清HCV-RNA呈阴性，而在85名HBsAg阴性的患者中只有9名（10%）出现这种情况（P = 0.02）。在对年龄、抗逆转录病毒治疗、血浆HIV-RNA和CD4细胞计数进行校正后，HBsAg阳性与血清HCV-RNA阴性密切相关（比值比：23；95%置信区间：6-59；P < 0.001）。因此，HBV可能有利于HIV感染患者体内HCV的清除，这可能会影响肝脏疾病和治疗决策。