Variations in cervical IL-10 and IL-8 concentrations throughout gestation in normal pregnancies.
作者信息
Mondestin-Sorrentino Myriam, Smulian John C, Vintzileos Anthony M, Sorrentino David, Ananth Cande V, Sharma Surendra, Hanna Nazeeh N
机构信息
Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, Jersey Shore University Medical Center, Neptune, NJ, USA.
出版信息
Am J Reprod Immunol. 2007 Jun;57(6):482-7. doi: 10.1111/j.1600-0897.2007.00468.x.
PROBLEM
Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited.
METHOD OF STUDY
This was a cross sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova.
RESULTS
The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210-4100), 2460 (1047-4688), 3660 (1451-4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8-227.9), 10.9 (0-263.3), 9.5 (0-35.6); the mean IL10/IL-8 x 100 (+/- standard deviation) concentrations were: 3.33 +/- 0.65, 1.47 +/- 0.41, 0.38 +/- 0.52 (P = 0.0035) during the first, second and third trimesters, respectively.
CONCLUSION
The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation.
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