Hattori Yukio, Nakanishi Tamao, Ozaki Yasuhiko, Nozawa Kyoko, Sato Takeshi, Sugiura-Ogasawara Mayumi
Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan.
Am J Reprod Immunol. 2007 Oct;58(4):350-7. doi: 10.1111/j.1600-0897.2007.00516.x.
Inflammatory changes frequently occur in cases of second trimester miscarriage or pre-term delivery, but little attention has been paid to this association with recurrent miscarriage. As interleukin-6 and interleukin-8 are inflammatory cytokines reported to be associated with bacterial vaginosis, intrauterine infections, and pre-term delivery, we here investigated whether they might have predictive value for spontaneous abortion in recurrent cases.
Cervical mucus and sera were collected at 4-5 weeks' gestation from a total of 59 patients with a history of two or more unexplained consecutive first trimester miscarriages, and examined by enzyme-linked immunosorbent assay. Patients then were followed up without medication and their pregnancy outcomes were compared with the test results.
Of a total of 59 patients, 13 (22%) miscarried subsequently. Both IL-6 and IL-8 in cervical mucus were significantly higher in patients who miscarried subsequently than in those who had a live birth. In addition, there was no correlation between cervical mucus and serum concentrations of IL-6 and IL-8 take at the same time, and there was no relation with serum IL-6 and IL-8 levels between the two groups.
Cervical IL-6 and IL-8 might have predictive value for cases of recurrent miscarriage.
孕中期流产或早产病例中经常出现炎症变化，但这种与复发性流产的关联很少受到关注。由于白细胞介素-6和白细胞介素-8是据报道与细菌性阴道病、宫内感染和早产相关的炎症细胞因子，我们在此研究它们是否可能对复发性病例中的自然流产具有预测价值。
从总共59例有两次或更多次不明原因的连续孕早期流产病史的患者中，在妊娠4-5周时收集宫颈黏液和血清，并通过酶联免疫吸附测定法进行检测。然后对患者进行无药物随访，并将其妊娠结局与检测结果进行比较。
在总共59例患者中，有13例（22%）随后流产。随后流产的患者宫颈黏液中的白细胞介素-6和白细胞介素-8均显著高于活产患者。此外，同一时间采集的宫颈黏液和血清中白细胞介素-6和白细胞介素-8的浓度之间没有相关性，两组之间血清白细胞介素-6和白细胞介素-8水平也没有关系。
宫颈白细胞介素-6和白细胞介素-8可能对复发性流产病例具有预测价值。
