在正常妊娠中，全身白细胞介素-10浓度在孕早期和孕中期之间无变化。
Systemic interleukin-10 concentrations do not alter between the first and second trimester in normal pregnancy.
作者信息
van der Weiden R M F, Janssen J W, Stegeman M
机构信息
Department of Obstetrics and Gynecology, Sint Franciscus Gasthuis, Kleiweg 500, 3045, Rotterdam, The Netherlands.
出版信息
Arch Gynecol Obstet. 2005 Dec;273(3):150-1. doi: 10.1007/s00404-005-0031-0. Epub 2005 Jul 14.
BACKGROUND
Interleukin 10 (IL-10) is involved in normal fecundity and systemic IL-10 changes during gestation might reflect an immunologic shift at the maternal-fetal interface.
METHODS
Serum IL-10 levels were measured in the first and second trimester of uncomplicated pregnancy in 32 women. The low interassay coefficient of variation of the low adjustor of the IL-10 assay (5.2%) enabled us to detect IL-10 concentrations between 0.50 pg/ml and 4.0 pg/ml.
RESULTS
There was no statistically significant difference between serum IL-10 levels in the first trimester (median 1.10; range 0.53-4.60 pg/ml) and second trimester (median 1.05; range 0.64-3.30 pg/ml).
CONCLUSION
IL-10 is not systemically activated to a detectable degree between the first and second trimester of normal pregnancy.
背景
白细胞介素10（IL-10）参与正常生育，孕期全身IL-10的变化可能反映母胎界面的免疫转变。
方法
对32名无并发症妊娠妇女的孕早期和孕中期血清IL-10水平进行了测定。IL-10检测的低校正剂的低批间变异系数（5.2%）使我们能够检测到0.50 pg/ml至4.0 pg/ml之间的IL-10浓度。
结果
孕早期（中位数1.10；范围0.53 - 4.60 pg/ml）和孕中期（中位数1.05；范围0.64 - 3.30 pg/ml）的血清IL-10水平之间无统计学显著差异。
结论
在正常妊娠的孕早期和孕中期之间，IL-10未被全身激活至可检测程度。
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