Zhang Zhengdong D, Rozowsky Joel, Lam Hugo Y K, Du Jiang, Snyder Michael, Gerstein Mark
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Genome Biol. 2007;8(5):R81. doi: 10.1186/gb-2007-8-5-r81.
We developed Tilescope, a fully integrated data processing pipeline for analyzing high-density tiling-array data http://tilescope.gersteinlab.org. In a completely automated fashion, Tilescope will normalize signals between channels and across arrays, combine replicate experiments, score each array element, and identify genomic features. The program is designed with a modular, three-tiered architecture, facilitating parallelism, and a graphic user-friendly interface, presenting results in an organized web page, downloadable for further analysis.