Shugaleĭ V S, Ananian A A, Miliutina N P, Chin Kim T T
Vopr Med Khim. 1991 Jul-Aug;37(4):51-4.
Arginine, preadministered intraperitoneally at a dose of 120 mg per 100 g of body mass before hypoxia, decreased content of diene conjugates by 42-64% and Schiff bases by 7-15% in rat liver and testicular microsomal membranes as compared with control rats nontreated with arginine. Under these conditions cytochrome P-450 catalytic activity with aniline as a substrate was increased by 65-152% and with amidopyrine as a substrate--by 72-148%, respectively. Exogenous arginine inhibited an increase in membranes microviscosity, specific for hypoxic state; relative microviscosity of lipid bilayer was decreased by 36% and of the protein-lipid contact zones--by 84% as compared with control hypoxic animals.
在缺氧前以每100克体重120毫克的剂量腹腔注射精氨酸，与未用精氨酸处理的对照大鼠相比，大鼠肝脏和睾丸微粒体膜中二烯共轭物的含量降低了42 - 64%，席夫碱的含量降低了7 - 15%。在这些条件下，以苯胺为底物时细胞色素P - 450的催化活性分别提高了65 - 152%，以氨基比林为底物时提高了72 - 148%。外源性精氨酸抑制了对缺氧状态具有特异性的膜微粘度增加；与对照缺氧动物相比，脂质双层的相对微粘度降低了36%，蛋白质 - 脂质接触区的相对微粘度降低了84%。
