[精氨酸的抗自由基和抗氧化作用及其对缺氧时脂质过氧化的影响]
[Antiradical and antioxidant effect of arginine and its action on lipid peroxidation in hypoxia].
作者信息
Miliutina N P, Ananian A A, Shugaleĭ V S
出版信息
Biull Eksp Biol Med. 1990 Sep;110(9):263-5.
PMID:2176554
Abstract
Arginine (0.5 and 1 mu mol) decreased by 14-17% rates of superoxide anion formation in two systems: HADH-phenazine methosulfate and hydroxylamine autooxidation with nitrotetrazolium blue. These concentrations of arginine decreased by 40-50% formation of diene conjugates and Schiff bases in plasma when lipid peroxidation initiated by iron -ascorbate. Arginine administration before hypoxia decreased lipid peroxidation rate in plasma and liver microsomal membranes of rats.
摘要
精氨酸（0.5和1微摩尔）在两个系统中使超氧阴离子形成速率降低了14% - 17%：即肝醇脱氢酶 - 吩嗪硫酸甲酯系统以及用氯化硝基四氮唑蓝进行的羟胺自氧化系统。当由铁 - 抗坏血酸引发脂质过氧化时，这些浓度的精氨酸使血浆中二烯共轭物和席夫碱的形成减少了40% - 50%。在缺氧前给予精氨酸可降低大鼠血浆和肝微粒体膜中的脂质过氧化速率。
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