SanGiovanni John Paul, Chew Emily Y, Clemons Traci E, Davis Matthew D, Ferris Frederick L, Gensler Gary R, Kurinij Natalie, Lindblad Anne S, Milton Roy C, Seddon Johanna M, Sperduto Robert D
AREDS Coordinating Center, The EMMES Corporation, 401 N. Washington Street, Rockville, MD 20850, USA.
Arch Ophthalmol. 2007 May;125(5):671-9. doi: 10.1001/archopht.125.5.671.
To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS).
Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N = 4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen).
Dietary total omega-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal omega-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups.
Higher intake of omega-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.
在年龄相关性眼病研究（AREDS）中评估脂质摄入量与年龄相关性黄斑变性（AMD）基线严重程度之间的关联。
年龄相关性眼病研究中入组时年龄在60至80岁的参与者（N = 4519）通过自行填写的半定量食物频率问卷提供习惯性营养素摄入量的估计值。使用立体彩色眼底照片将参与者分为4个AMD严重程度组和1个对照组（玻璃膜疣小于15个的参与者）。
在调整总能量摄入和协变量后，将摄入量最高与最低五分位数进行比较，膳食总ω-3长链多不饱和脂肪酸（LCPUFA）摄入量与新生血管性（NV）AMD呈负相关（优势比[OR]，0.61；95%置信区间[CI]，0.41 - 0.90），视网膜ω-3 LCPUFA二十二碳六烯酸也是如此（OR，0.54；95% CI，0.36 - 0.80）。较高的鱼类总消费量以及烤/煎鱼类消费量也与NV AMD呈负相关（分别为OR，0.61；95% CI，0.37 - 1.00和OR，0.65；95% CI，0.45 - 0.93）。膳食花生四烯酸与NV AMD患病率呈正相关（OR，1.54；95% CI，1.04 - 2.29）。其他脂质与AMD各亚组之间不存在统计学上的显著关系。
较高的ω-3 LCPUFA和鱼类摄入量与发生NV AMD的可能性降低相关。
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