Witt C S, Pomat W
Royal Perth Hospital, Australia.
P N G Med J. 1991 Sep;34(3):211-4.
The immune response of pneumonia patients and controls to Streptococcus pneumoniae was investigated by enzyme-linked immunosorbent assay (ELISA). Patients less than 6 months of age had significantly lower levels of anti-pneumococcal polysaccharide antibodies than their age-matched controls. Patients and controls 6-14 months of age had lower antibody levels than the children 0-5 months of age. Adult patients and controls did not differ in their antibody status. However, patients and Papua New Guinean controls had depressed cell-mediated immunity and low T-cell numbers. Low levels of antibodies to pneumococcal polysaccharides in children less than 6 months of age appear to be an important risk factor for acute lower respiratory tract infections but other factors may be important in older infants and adults.
通过酶联免疫吸附测定（ELISA）研究了肺炎患者和对照组对肺炎链球菌的免疫反应。6个月以下的患者抗肺炎球菌多糖抗体水平明显低于年龄匹配的对照组。6至14个月的患者和对照组抗体水平低于0至5个月的儿童。成年患者和对照组的抗体状况没有差异。然而，患者和巴布亚新几内亚对照组的细胞介导免疫受到抑制，T细胞数量较低。6个月以下儿童肺炎球菌多糖抗体水平低似乎是急性下呼吸道感染的一个重要危险因素，但其他因素在较大婴儿和成年人中可能也很重要。
