Witt C S, Alpers M P
Papua New Guinea Institute of Medical Research, Goroka.
P N G Med J. 1991 Jun;34(2):90-7.
Immune function was studied in Papua New Guinea highland infants with pneumonia, healthy highland controls and expatriate controls under the age of 15 months. Delayed-type hypersensitivity to tuberculin was depressed in highland pneumonia patients and highland controls as were CD4/CD8 T-lymphocyte ratios. The differences between highland and expatriate infants were more pronounced after 6 months of age, suggesting an environmental effect. Serum immunoglobulin and complement concentrations were higher in highland infants than in expatriate controls. Indices of nutritional status were similar in highland and expatriate infants but iron deficiency was more common in the highland infants in the study.
对巴布亚新几内亚高地患有肺炎的婴儿、健康的高地对照婴儿以及15个月以下的外籍对照婴儿的免疫功能进行了研究。高地肺炎患者和高地对照婴儿对结核菌素的迟发型超敏反应以及CD4/CD8 T淋巴细胞比率均降低。高地婴儿和外籍婴儿之间的差异在6个月龄后更为明显，提示存在环境影响。高地婴儿的血清免疫球蛋白和补体浓度高于外籍对照婴儿。高地婴儿和外籍婴儿的营养状况指标相似，但本研究中缺铁在高地婴儿中更为常见。
