Witt C S, Pomat W, Lehmann D, Alpers M P
Papua New Guinea Institute of Medical Research, Goroka.
Clin Exp Immunol. 1991 Feb;83(2):219-24. doi: 10.1111/j.1365-2249.1991.tb05618.x.
Antibodies against pneumococcal polysaccharides were measured by ELISA in Papua New Guinean children with pneumonia aged 0-14 months, in age-matched healthy Papua New Guinean controls and in healthy expatriate children living in Papua New Guinea. At 0-5 months of age, the IgG antibody titres against six of the eight polysaccharides measured were significantly lower in pneumonia patients than in both control groups. Antibody titres in 6-14-month-old Papua New Guinean controls were significantly lower than in control Papua New Guineans aged 0-5 months for five of the eight polysaccharides tested. In the 6-14-months age group the antibody titre was significantly lower in pneumonia patients than in controls for only one polysaccharide. For seven of the eight serotypes tested, antibody levels in expatriate controls did not decline with age. Antibody responses of Papua New Guinean children aged 6-18 months to a 23-valent pneumococcal vaccine were serotype dependent. Fold increases in response to the vaccine were greatest for the IgA isotype. IgG antibody responses were greater than three fold to four of the eight serotypes tested.
通过酶联免疫吸附测定法（ELISA），对巴布亚新几内亚0至14个月大患肺炎的儿童、年龄匹配的巴布亚新几内亚健康对照儿童以及居住在巴布亚新几内亚的健康外籍儿童，检测其抗肺炎球菌多糖抗体。在0至5个月大时，所检测的8种多糖中，有6种的IgG抗体滴度在肺炎患者中显著低于两个对照组。在6至14个月大的巴布亚新几内亚对照儿童中，所检测的8种多糖中有5种的抗体滴度显著低于0至5个月大的巴布亚新几内亚对照儿童。在6至14个月龄组中，仅有一种多糖的肺炎患者抗体滴度显著低于对照组。在所检测的8种血清型中，有7种在外籍对照儿童中抗体水平不随年龄下降。6至18个月大的巴布亚新几内亚儿童对23价肺炎球菌疫苗的抗体反应具有血清型依赖性。对疫苗反应的倍数增加在IgA同种型中最大。在所检测的8种血清型中，有4种的IgG抗体反应大于三倍。
