Carretero Blanca, Martín Ma José, Juan Antonio, Pradana Ma Luz, Martín Beatriz, Carral Maria, Jimeno Teresa, Pareja Antonio, Montoya Pedro, Aguirre Iratxe, Salva Joan, Roca Miguel, Gili Margalida, Garcia-Toro Mauro
Hospital Son Llatzer, Palma de Mallorca, Spain.
Pain Med. 2009 May-Jun;10(4):748-53. doi: 10.1111/j.1526-4637.2009.00625.x. Epub 2009 May 4.
OBJECTIVE: To study the efficacy of low-frequency transcranial magnetic stimulation in patients with fibromyalgia and major depression. DESIGN: Twenty-eight patients were randomly assigned to receive 20 sessions of real or sham transcranial magnetic stimulation of the right dorsolateral prefrontal cortex. The main stimulation parameters were 15 trains at 110% of the motor threshold for 60 seconds at a frequency of 1 Hz. Blinded external evaluators administered the fibromyalgia scales (FibroFatigue, Likert pain) and the depression scales (Hamilton Depression Rating Scale, Clinical Global Impression) during the study. RESULTS: Both treatment groups (real and sham) improved their scores in some of the scales (FibroFatigue and Clinical Global Impression), although there were no differences between them. No improvements were observed in the Likert Pain Scale in either of the groups. CONCLUSION: With the methodology used in this study, patients with fibromyalgia and major depression who received real magnetic stimulation did not present significant differences in symptoms with respect to those who received sham magnetic stimulation.
目的：研究低频经颅磁刺激对纤维肌痛合并重度抑郁症患者的疗效。 设计：28名患者被随机分配接受20次对右侧背外侧前额叶皮质进行的真实或假性经颅磁刺激。主要刺激参数为以运动阈值的110%进行15串刺激，频率为1赫兹，持续60秒。在研究过程中，由不知情的外部评估者使用纤维肌痛量表（纤维肌痛疲劳量表、李克特疼痛量表）和抑郁量表（汉密尔顿抑郁评定量表、临床总体印象量表）进行评估。 结果：两个治疗组（真实刺激组和假性刺激组）在某些量表（纤维肌痛疲劳量表和临床总体印象量表）上的得分均有所改善，尽管两组之间没有差异。两组在李克特疼痛量表上均未观察到改善。 结论：采用本研究中的方法，接受真实磁刺激的纤维肌痛合并重度抑郁症患者与接受假性磁刺激的患者在症状方面没有显著差异。
J Affect Disord. 2010-11-18
Pain Med. 2006
Zotero 插件