Fitzgerald Paul B, McQueen Susan, Herring Sally, Hoy Kate, Segrave Rebecca, Kulkarni Jayashri, Daskalakis Zafiris J
Alfred Psychiatry Research Centre, The Alfred and Monash University Department of Psychological Medicine, Commercial Road, Melbourne, Victoria 3004, Australia.
Psychiatry Res. 2009 Aug 30;169(1):12-5. doi: 10.1016/j.psychres.2008.06.017. Epub 2009 Jul 23.
The objective of this study was to explore the response rate to high-frequency left-sided repetitive transcranial magnetic stimulation (rTMS) in patients who had failed to respond to right-sided low-frequency stimulation, and to investigate whether there was differential efficacy between stimulation at 5 or 10 Hz. Data from two randomized controlled trials were pooled. In both studies a group of patients were randomized to receive either 5- or 10-Hz left prefrontal rTMS after failing to respond to right-sided stimulation. These patients received blinded 5- or 10-Hz stimulation (but without a sham control) for a period of up to 4 weeks and outcomes were compared. There was a small but significant overall response to left-sided rTMS but no difference in response between the 5- and 10-Hz treatment conditions. There appears to be a significant but modest likelihood of response to left-sided TMS in patients who fail right-sided stimulation, but there is no difference in efficacy between 5- and 10-Hz stimulation.
本研究的目的是探讨对右侧低频刺激无反应的患者对高频左侧重复经颅磁刺激（rTMS）的反应率，并研究5赫兹或10赫兹刺激之间是否存在疗效差异。汇总了两项随机对照试验的数据。在两项研究中，一组患者在对右侧刺激无反应后，被随机分配接受5赫兹或10赫兹的左侧前额叶rTMS。这些患者接受了长达4周的盲法5赫兹或10赫兹刺激（但没有假刺激对照），并比较了结果。左侧rTMS有一个小但显著的总体反应，但5赫兹和10赫兹治疗条件之间的反应没有差异。在右侧刺激失败的患者中，对左侧TMS有显著但适度的反应可能性，但5赫兹和10赫兹刺激之间的疗效没有差异。
