Oswald Robert E, Ahmed Ahmed, Fenwick Michael K, Loh Adrienne P
Department of Molecular Medicine, C3-167 VMC, Cornell University, Ithaca, NY 14853, USA.
Curr Drug Targets. 2007 May;8(5):573-82. doi: 10.2174/138945007780618526.
Glutamate receptors mediate a vast array of processes in plants, animals and bacteria. In particular, the ionotropic glutamate receptors (iGluRs) are the most abundant excitatory neurotransmitter receptors in the mammalian central nervous system. Because these proteins are constructed from distinct folding domains, most of which can be traced to bacterial precursors, the analyses of these important receptor proteins has been performed on a variety of levels ranging from atomic structure and dynamics to behavioral studies. This review will focus on the structure and dynamics of iGluRs, with particular emphasis on the role that the glutamate-binding domain (S1S2) plays in receptor function.
谷氨酸受体介导植物、动物和细菌中的大量生理过程。特别是，离子型谷氨酸受体（iGluRs）是哺乳动物中枢神经系统中最丰富的兴奋性神经递质受体。由于这些蛋白质由不同的折叠结构域构成，其中大多数可追溯到细菌前体，因此对这些重要受体蛋白的分析已在从原子结构和动力学到行为研究的各种层面上进行。本综述将聚焦于离子型谷氨酸受体的结构和动力学，特别强调谷氨酸结合结构域（S1S2）在受体功能中所起的作用。
