E-钙黏蛋白、β-连环蛋白与犬恶性乳腺肿瘤的侵袭及淋巴结转移

E-cadherin, beta-catenin, invasion and lymph node metastases in canine malignant mammary tumours.

作者信息

De Matos Augusto José Ferreira, Lopes Célia Cristina Carreiras, Faustino Augusto Manuel Rodrigues, Carvalheira Júlio Gil Vale, Rutteman Gerard Roel, Gärtner Maria De Fátima Rodrigues Moutinho

机构信息

Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, Porto, Portugal.

出版信息

APMIS. 2007 Apr;115(4):327-34. doi: 10.1111/j.1600-0463.2007.apm_544.x.

DOI:10.1111/j.1600-0463.2007.apm_544.x

PMID:17504299

Abstract

Recent studies of canine malignant mammary tumours suggest that reduction of E-cadherin and/or beta-catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E-cadherin and beta-catenin, and the relationship between the expression of E-cadherin and/or beta-catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant tumours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E-cadherin and beta-catenin (p=0.0027), but not between E-cadherin and cytoplasmic beta-catenin. Only E-cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic beta-catenin expression was significantly related to either of these phenomena.

摘要

近期对犬恶性乳腺肿瘤的研究表明，E-钙黏蛋白和/或β-连环蛋白的减少与侵袭行为及淋巴结转移相关。本研究的目的是检测E-钙黏蛋白和β-连环蛋白表达之间的相互关系，以及E-钙黏蛋白和/或β-连环蛋白表达与犬恶性乳腺肿瘤生长方式及转移能力之间的关系。对90个自发性恶性肿瘤及局部和区域淋巴结进行了研究。E-钙黏蛋白和β-连环蛋白的膜表达之间存在显著相关性（p = 0.0027），但E-钙黏蛋白与细胞质β-连环蛋白之间无显著相关性。仅E-钙黏蛋白作为一个独立因素与肿瘤侵袭（p = 0.0072）和淋巴结转移（p = 0.0001）显著相关。膜性或细胞质β-连环蛋白表达与上述任何一种现象均无显著相关性。