Matos A J F, Lopes C, Carvalheira J, Santos M, Rutteman G R, Gärtner F
Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Portugal.
J Comp Pathol. 2006 Feb-Apr;134(2-3):182-9. doi: 10.1016/j.jcpa.2005.10.004. Epub 2006 Mar 20.
The relationship between E-cadherin epithelial expression, as detected by immunohistochemical methods, and other clinico-pathological characteristics of canine malignant mammary tumours was studied in 77 tumours surgically removed from 45 female dogs. The immunohistochemical assessment was based on the estimated percentage of epithelial cells with membranous labelling. Reduction of E-cadherin expression was significantly related to size and ulceration of tumours but not to fixation to skin or underlying tissue; it was also related to lymph node metastasis, necrosis and infiltrative growth. Histological type (but not histological grade) was related to E-cadherin expression, with solid tumours more frequently lacking expression and tubulopapillary tumours showing increased expression as compared with the other types. The significant relationship between E-cadherin and other known factors of poor prognosis suggests that the loss of E-cadherin expression may have prognostic value in canine malignant mammary tumours.
在从45只雌性犬手术切除的77个肿瘤中，研究了通过免疫组织化学方法检测到的E-钙黏蛋白上皮表达与犬恶性乳腺肿瘤的其他临床病理特征之间的关系。免疫组织化学评估基于具有膜标记的上皮细胞的估计百分比。E-钙黏蛋白表达的降低与肿瘤的大小和溃疡显著相关，但与皮肤或下方组织的固定无关；它还与淋巴结转移、坏死和浸润性生长有关。组织学类型（而非组织学分级）与E-钙黏蛋白表达有关，实体瘤比其他类型更常缺乏表达，而管状乳头状瘤则显示表达增加。E-钙黏蛋白与其他已知预后不良因素之间的显著关系表明，E-钙黏蛋白表达的丧失可能对犬恶性乳腺肿瘤具有预后价值。
