Fentiman I S, Allen D S, Ellison G T H
Academic Oncology Unit, Guy's Hospital, London, UK.
Int J Clin Pract. 2007 Jun;61(6):937-43. doi: 10.1111/j.1742-1241.2007.01288.x.
To examine the impact of the German Occupation of Guernsey (1940-1945) on breast cancer risk factors and incidence. Under study were 1019 women who stayed, or whose mothers had stayed, in Guernsey, and 1358 women evacuated or born to evacuated mothers. Amongst those born 1926-1934 who remained in Guernsey, the secular trend of earlier menarche disappeared: menarche was delayed by 12 months for those born in 1930. By March 2006, 97 breast cancers had been diagnosed, 37 in the occupied group. Unusually, higher age at menarche appeared to be associated with increased risk of breast cancer (>or=14 years vs. <or=13 years: HR = 1.52, 95% CI = 0.80-2.92). Separate analyses by birth cohort revealed a non-significantly higher incidence in the subgroup born from 1926 to 1934 (HR = 1.30, 95% CI = 0.62-2.76). Delay in menarche among women remaining in Guernsey during the Occupation, rather than being protective, was associated with an increased risk of breast cancer.
研究德国占领根西岛（1940 - 1945年）对乳腺癌风险因素及发病率的影响。研究对象包括1019名留在根西岛或其母亲曾留在根西岛的女性，以及1358名被疏散或母亲为被疏散人员的女性。在1926年至1934年出生且留在根西岛的人群中，月经初潮提前的长期趋势消失了：1930年出生的人群月经初潮推迟了12个月。到2006年3月，已诊断出97例乳腺癌，其中被占领组有37例。不同寻常的是，月经初潮年龄较大似乎与乳腺癌风险增加有关（≥14岁 vs. ≤13岁：风险比 = 1.52，95%置信区间 = 0.80 - 2.92）。按出生队列进行的单独分析显示，1926年至1934年出生的亚组发病率略高但无统计学意义（风险比 = 1.30，95%置信区间 = 0.62 - 2.76）。占领期间留在根西岛的女性月经初潮推迟，非但没有起到保护作用，反而与乳腺癌风险增加有关。
