Weisz George M, Albury William R
Department of Orthopaedics, Sydney Wolper Jewish Hospital, School of Humanities, University of New England, Armidale, NSW, Australia, and School of Humanities (Program in History of Medicine), University of NSW, Sydney, Australia and.
School of Humanities, University of New England, Armidale, NSW, Australia.
Rambam Maimonides Med J. 2014 Jan 21;5(1):e0004. doi: 10.5041/RMMJ.10138. eCollection 2014 Jan.
The fetal "programming of adult diseases" has been previously reviewed. The descriptions were comprehensive, dealing with the effects of nutritional deprivation on the development of adult metabolic and cardiovascular diseases. During the past decade, research into this "programming" also expanded to the development of osteoporosis. The present review deals with the imbalance of bone mineral metabolism, "programmed" by maternal/fetal/infantile nutritional deprivation, and is illustrated with a family history from the Budapest Ghetto.
胎儿“成人疾病编程”此前已有综述。相关描述全面,涉及营养剥夺对成人代谢和心血管疾病发展的影响。在过去十年中,对这种“编程”的研究还扩展到了骨质疏松症的发展。本综述探讨了由母体/胎儿/婴儿期营养剥夺“编程”的骨矿物质代谢失衡,并以布达佩斯犹太人区的一个家族病史为例进行说明。