Jones Graham
Institute for Immunology and Allergy Research, ICPMR Building, Westmead Hospital, Westmead, NSW, 2145, Australia.
Curr Allergy Asthma Rep. 2007 Apr;7(1):11-7. doi: 10.1007/s11882-007-0025-z.
The past several years have seen an increase in the rate at which genes that are associated with allergic asthma and eczema are discovered. This review -examines genetic association, gene expression, and functional studies that have identified genes that are expressed in the epithelial cells of the skin and lung and are involved in the pathogenesis of allergic asthma and eczema. This includes the genes encoding thymic stromal lympho-poietin (TSLP) and suppressor of cytokine signaling (SOCS3) that are involved in the activation of T-helper 2 cells, the microbial pattern recognition receptors nucleotide-binding oligomerization domain (NOD) genes (CARD4 and CARD15), Toll-like receptors (TLR2 and TLR4), and filaggrin, a protein required for effective barrier defense of the skin. Therefore, the development of allergic disease involves both the adaptive and innate immune systems, and the expression of these genes in the skin and lungs suggests a link to environmental -triggers at body surfaces.
在过去几年中，与过敏性哮喘和湿疹相关的基因的发现率有所上升。本综述探讨了基因关联、基因表达及功能研究，这些研究确定了在皮肤和肺的上皮细胞中表达且参与过敏性哮喘和湿疹发病机制的基因。这包括编码胸腺基质淋巴细胞生成素（TSLP）和细胞因子信号转导抑制因子（SOCS3）的基因，它们参与辅助性T2细胞的激活；微生物模式识别受体核苷酸结合寡聚化结构域（NOD）基因（CARD4和CARD15）、Toll样受体（TLR2和TLR4）以及丝聚合蛋白，后者是皮肤有效屏障防御所需的一种蛋白质。因此，过敏性疾病的发展涉及适应性免疫系统和先天性免疫系统，而这些基因在皮肤和肺部的表达表明与体表的环境触发因素存在联系。
