Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds N J, Meggitt S J, Kere J, Wahlgren C-F, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M
Department of Molecular Medicine and Surgery, Department of Medicine, Karolinska University Hospital, Stockholm, SE-171 76, Sweden.
Am J Hum Genet. 2006 Jun;78(6):1060-5. doi: 10.1086/504272. Epub 2006 Apr 14.
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
在一项对全球基因表达模式的系统分析中，我们发现，与健康对照者的皮肤相比，特应性皮炎患者皮肤中SOCS3信使核糖核酸的表达显著更高，免疫组织化学分析证实SOCS3蛋白也有类似程度的升高。此外，我们在两组独立的患者中发现特应性皮炎与SOCS3基因中的一个单倍型存在遗传关联（P<0.02和P<0.03）。这些结果有力地表明，位于先前与该疾病相关的染色体区域（17q25）的SOCS3是特应性皮炎的一个易感基因。
