SOCS3基因的高表达及基因关联性与特应性皮炎相关。
Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
作者信息
Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, Reynolds N J, Meggitt S J, Kere J, Wahlgren C-F, Pershagen G, Wickman M, Nordenskjold M, Kockum I, Bradley M
机构信息
Department of Molecular Medicine and Surgery, Department of Medicine, Karolinska University Hospital, Stockholm, SE-171 76, Sweden.
出版信息
Am J Hum Genet. 2006 Jun;78(6):1060-5. doi: 10.1086/504272. Epub 2006 Apr 14.
Abstract
In a systematic analysis of global gene-expression patterns, we found that SOCS3 messenger RNA was significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls, and immunohistochemical analysis confirmed a similar elevation of SOCS3 protein. Furthermore, we found a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene in two independent groups of patients (P<.02 and P<.03). These results strongly suggest that SOCS3, located in a chromosomal region previously linked to the disease (17q25), is a susceptibility gene for atopic dermatitis.
摘要
在一项对全球基因表达模式的系统分析中，我们发现，与健康对照者的皮肤相比，特应性皮炎患者皮肤中SOCS3信使核糖核酸的表达显著更高，免疫组织化学分析证实SOCS3蛋白也有类似程度的升高。此外，我们在两组独立的患者中发现特应性皮炎与SOCS3基因中的一个单倍型存在遗传关联（P<0.02和P<0.03）。这些结果有力地表明，位于先前与该疾病相关的染色体区域（17q25）的SOCS3是特应性皮炎的一个易感基因。
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本文引用的文献
1
Online Mendelian Inheritance in Man 'OMIM'.《人类孟德尔遗传在线》（OMIM）。
Indian J Dermatol Venereol Leprol. 2003 Nov-Dec;69(6):423-4.
2
Absence of association between asthma and high serum immunoglobulin E associated GPRA haplotypes and adult atopic dermatitis.哮喘与高血清免疫球蛋白E相关的GPRA单倍型及成人特应性皮炎之间无关联。
J Invest Dermatol. 2005 Aug;125(2):399-401. doi: 10.1111/j.0022-202X.2005.23828.x.
3
Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation.白细胞介素-9受体单倍型对儿童喘息和致敏的性别特异性保护作用。
J Med Genet. 2004 Dec;41(12):e123. doi: 10.1136/jmg.2004.023135.
4
Sp3 is involved in the regulation of SOCS3 gene expression.Sp3参与SOCS3基因表达的调控。
Biochem J. 2005 May 1;387(Pt 3):737-45. doi: 10.1042/BJ20041101.
5
Atopic dermatitis -- a total genome-scan for susceptibility genes.
Acta Derm Venereol. 2004;84(5):346-52. doi: 10.1080/00015550410034426.
6
Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003.全球通用的过敏症修订命名法：世界过敏组织命名法审查委员会报告，2003年10月
J Allergy Clin Immunol. 2004 May;113(5):832-6. doi: 10.1016/j.jaci.2003.12.591.
7
On estimating the relation between blood group and disease.关于评估血型与疾病之间的关系。
Ann Hum Genet. 1955 Jun;19(4):251-3. doi: 10.1111/j.1469-1809.1955.tb01348.x.
8
Pedigree disequilibrium tests for multilocus haplotypes.多位点单倍型的系谱不平衡检验
Genet Epidemiol. 2003 Sep;25(2):115-21. doi: 10.1002/gepi.10252.
9
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.细胞因子信号转导抑制因子3调控辅助性T细胞2介导的过敏反应的起始和维持。
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10
The BAMSE project: presentation of a prospective longitudinal birth cohort study.BAMSE项目：一项前瞻性纵向出生队列研究的介绍
Pediatr Allergy Immunol. 2002;13(s15):11-3. doi: 10.1034/j.1399-3038.13.s.15.10.x.
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