Jacobsen Elizabeth A, Ochkur Sergei I, Lee Nancy A, Lee James J
Division of Pulmonary Medicine, SCJMRB-RESEARCH, Mayo Clinic Arizona, 13400 E. Shea Boulevard, Scottsdale, AZ 85259, USA.
Curr Allergy Asthma Rep. 2007 Apr;7(1):18-26. doi: 10.1007/s11882-007-0026-y.
Recruitment and activation of eosinophils into the airways of asthma patients is suggested to be a contributing causative agent in the histopathologies and lung dysfunction that are characteristic of asthma. Recent studies in mouse models of asthma and in human patients implicate eosinophils in immune regulation and remodeling in the lung in addition to their hypothesized role as destructive agents. Specifically, eosinophils not only participate in release of granule proteins, lipid mediators, reactive oxygen species, cytokines, and growth factors but also function through complex cell-cell interactions to elicit chronic T helper 2 inflammation in the lung. This review highlights the roles of eosinophils in asthma.
嗜酸性粒细胞被招募并激活进入哮喘患者的气道，被认为是哮喘所特有的组织病理学和肺功能障碍的一个致病因素。最近在哮喘小鼠模型和人类患者中的研究表明，嗜酸性粒细胞除了其作为破坏因子的假定作用外，还参与肺部的免疫调节和重塑。具体而言，嗜酸性粒细胞不仅参与颗粒蛋白、脂质介质、活性氧、细胞因子和生长因子的释放，还通过复杂的细胞间相互作用发挥作用，引发肺部慢性辅助性T细胞2炎症。这篇综述重点介绍了嗜酸性粒细胞在哮喘中的作用。
