Lee Yong-Wha, Min Won-Ki, Lee Woochang, Chun Sail, Park Hyosoon, Lee Do-Hoon, Lee You Kyoung
Department of Laboratory Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
J Clin Lab Anal. 2007;21(3):178-82. doi: 10.1002/jcla.20165.
The National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III), updated in 2001, quantified the risk factors and made it possible to assess risks for metabolic syndrome (MS) and coronary heart diseases (CHD). Many reported the prevalence of MS by NCEP ATP III in Orientals but few did risk analysis of CHD. We investigated the risk of CHD in Korean adults and the distribution of population for therapeutic lifestyle change (TLC) and drug therapy according to the NCEP ATP III guidelines. Based on ATP III risk factors, estimates of the 10-year risk for CHD on 16,383 Koreans and the distributions of population for the TLC and additional drug therapy by sex and age were calculated. High-, intermediate-, and low-risk groups were 8.1%, 24.1%, and 67.8%, respectively; 12.1% (high-, intermediate-, and low-risk groups: 32.0%, 45.1%, and 6.0%, respectively) needed TLC and 6.1% (high-, intermediate-, and low-risk groups: 39.4%, 16.6%, and 1.3%, respectively) needed additional drug therapy. The groups with higher risk needed more TLC and drug therapy. In the same age group, the rates of high risk in men showed a 1.0-6.6 fold increase compared with those in women. In Koreans, those who needed TLC and drug therapy were substantially lower than those in Americans.
2001年更新的美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）对风险因素进行了量化，从而能够评估代谢综合征（MS）和冠心病（CHD）的风险。许多研究报告了东方人按照NCEP ATP III标准诊断的MS患病率，但很少有研究对CHD进行风险分析。我们根据NCEP ATP III指南，调查了韩国成年人患CHD的风险以及治疗性生活方式改变（TLC）和药物治疗的人群分布情况。基于ATP III风险因素，计算了16383名韩国人患CHD的10年风险估计值以及按性别和年龄划分的TLC和额外药物治疗的人群分布情况。高风险、中风险和低风险组分别为8.1%、24.1%和67.8%；12.1%（高风险、中风险和低风险组分别为32.0%、45.1%和6.0%）需要TLC，6.1%（高风险、中风险和低风险组分别为39.4%、16.6%和1.3%）需要额外药物治疗。风险较高的组需要更多的TLC和药物治疗。在同一年龄组中，男性的高风险率比女性高1.0至6.6倍。在韩国人中，需要TLC和药物治疗的比例明显低于美国人。
