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追溯中国人的遗传历史:喇家遗址新石器时代人群的线粒体DNA分析

Tracing the genetic history of the Chinese people: mitochondrial DNA analysis of aneolithic population from the Lajia site.

作者信息

Gao Shi-Zhu, Yang Yi-Dai, Xu Yue, Zhang Quan-Chao, Zhu Hong, Zhou Hui

机构信息

Laboratory of Ancient DNA, Research Center for Chinese Frontier Archaeology of Jilin University, Changchun 130012, China.

出版信息

Am J Phys Anthropol. 2007 Aug;133(4):1128-36. doi: 10.1002/ajpa.20623.

DOI:10.1002/ajpa.20623
PMID:17506489
Abstract

Ancient DNA analysis was conducted on the dental remains of specimens from the Lajia site, dating back 3,800-4,000 years. The Lajia site is located in Minhe county, Qinghai province, in northwestern China. Archaeological studies link Lajia to the late period of the Qijia culture, one of the most important Neolithic civilizations of the upper Yellow River region, the cradle of Chinese civilization. Excavations at the site revealed that the inhabitants died in their houses as the result of a sudden flood. The Lajia site provides a rare chance to study the putative families, all of whom died at the same instant. Possible maternal familial relationships were investigated through mitochondrial DNA (mtDNA) sequence analysis. Twelve sequences from individuals found in one house were assigned to only five haplotypes, consistent with a possible close kinship. Results from analyses of RFLP typing and HVI motifs suggest that the Lajia people belonged to the haplogroups B, C, D, M*, and M10. This study, combined with archaeological and anthropological investigations, provides a better understanding of the genetic history of the Chinese people.

摘要

对来自喇家遗址的牙齿遗骸进行了古DNA分析,这些遗骸可追溯到3800至4000年前。喇家遗址位于中国西北部青海省民和县。考古研究将喇家与齐家文化晚期联系起来,齐家文化是黄河上游地区最重要的新石器文明之一,也是中华文明的摇篮。该遗址的发掘表明,居民因突发洪水死于家中。喇家遗址为研究假定的家族提供了难得的机会,这些家族成员均在同一时刻死亡。通过线粒体DNA(mtDNA)序列分析研究了可能的母系家族关系。在一所房屋中发现的12个个体的序列仅被归为5个单倍型,这与可能存在的近亲关系相符。RFLP分型和HVI基序分析结果表明,喇家人属于单倍群B、C、D、M*和M10。这项研究与考古学和人类学调查相结合,有助于更好地了解中国人的遗传历史。

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