微小RNA的功能

microRNA functions.

作者信息

Bushati Natascha, Cohen Stephen M

机构信息

Developmental Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany 69117.

出版信息

Annu Rev Cell Dev Biol. 2007;23:175-205. doi: 10.1146/annurev.cellbio.23.090506.123406.

DOI:10.1146/annurev.cellbio.23.090506.123406

PMID:17506695

Abstract

microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization. Here, we review recent work in animal models that provide insight into the diverse roles of miRNAs in vivo.

摘要

微小RNA（miRNA）是一类小的非编码RNA，在转录后基因调控中发挥重要作用。在动物细胞中，miRNA通过抑制翻译和使mRNA不稳定来调控其靶标。在此，我们综述了动物模型中的近期研究工作，这些工作为深入了解miRNA在体内的多种作用提供了线索。