Goto Sataro, Radak Zsolt
Department of Biochemistry, School of Pharmaceutical Sciences Toho University, Chiba, Japan.
Hungarian University of Sports Science Graduate School, Budapest, Hungary.
Adv Exp Med Biol. 2025;1478:317-342. doi: 10.1007/978-3-031-88361-3_13.
Model animals for aging research are described referring to the definition of biological aging, emphasizing importance of post-mitotic or slowly dividing cells in multicellular organisms. Selected theories of the molecular mechanisms of biological aging are examined in general including historical backgrounds on the genome instability theory of aging, free radical or oxidative stress theory of aging, mitochondrial theory of aging, error catastrophe theory of aging or translational error theory of aging, altered protein theory of aging or proteostasis theory of aging, and epigenetic theory of aging. The special relevance of these theories to the skeletal muscle aging are referred in each section.
根据生物衰老的定义描述了衰老研究的模式动物，强调了多细胞生物中后有丝分裂或缓慢分裂细胞的重要性。总体考察了生物衰老分子机制的选定理论，包括衰老的基因组不稳定性理论、自由基或氧化应激衰老理论、线粒体衰老理论、衰老的错误灾难理论或翻译错误理论、衰老的蛋白质改变理论或蛋白质稳态理论以及表观遗传衰老理论的历史背景。在每个部分都提到了这些理论与骨骼肌衰老的特殊相关性。
