Devoucoux R, Hurpin C, Baudon D, Molez J F, Roux J F, Guilloud-Bataille M, Carnevale P, Feingold J
Centre Muraz, Burkina Faso.
Ann Hum Biol. 1991 Jul-Aug;18(4):295-302. doi: 10.1080/03014469100001612.
The gene frequencies of haemoglobin A (HbA), HbS and HbC were studied in Burkina-Faso (BF) and in a neighbouring region of Niger, Ayorou. The frequency of HbS was higher in the Sahel region, (northern part of BF and Ayorou) than in the Savanna region. The reverse was true for the HbC gene. The major findings of this study are: (a) confirmation of a peak of HbC gene frequency in the central region of BF (Mossi plateau); (b) a possible negative correlation between the frequencies of HbS and HbC-Cavalli-Sforza and Bodmer have observed that this correlation is at a significantly different level from that expected because of the allelic relationship between HbS and HbC; (c) comparison with the data collected by Livingstone shows a modification in the fitness of the different genotypes in the last thirty years: AS individuals have a lower and AA and SS a higher fitness. Our data favour a partial selection relaxation in this region.
在布基纳法索（BF）和邻国尼日尔的阿约鲁地区，对血红蛋白A（HbA）、血红蛋白S（HbS）和血红蛋白C（HbC）的基因频率进行了研究。在萨赫勒地区（BF北部和阿约鲁），HbS的频率高于稀树草原地区。HbC基因的情况则相反。本研究的主要发现如下：（a）证实了BF中部地区（莫西高原）HbC基因频率出现峰值；（b）HbS和HbC频率之间可能存在负相关——卡瓦利-斯福扎和博德默观察到，由于HbS和HbC之间的等位基因关系，这种相关性与预期水平存在显著差异；（c）与利文斯通收集的数据相比，结果显示在过去三十年中不同基因型的适应性发生了变化：AS个体的适应性降低，而AA和SS个体的适应性提高。我们的数据表明该地区存在部分选择放松的情况。
