白细胞介素-21：免疫、感染和癌症的新型调节因子。

Interleukin-21: a new modulator of immunity, infection, and cancer.

作者信息

Brandt Katja, Singh Prim B, Bulfone-Paus Silvia, Rückert René

机构信息

Research Center Borstel, Department of Immunology and Cell Biology, Parkallee 22, Borstel, Germany.

出版信息

Cytokine Growth Factor Rev. 2007 Jun-Aug;18(3-4):223-32. doi: 10.1016/j.cytogfr.2007.04.003. Epub 2007 May 16.

DOI:10.1016/j.cytogfr.2007.04.003

PMID:17509926

Abstract

Interleukin-21 is the most recently discovered member of the type-I cytokine family. Structurally, IL-21 shows homology to IL-2, IL-4, and IL-15 proteins. IL-21 shares the common gamma-chain with the other three cytokines but, in addition, binds to a unique IL-21Ralpha chain, and activates the JAK/STAT pathway. IL-21 is mainly produced by activated T-cells but targets a broad range of lymphoid and myeloid cells of the immune system and therefore is able to regulate innate and acquired immune responses. This review intends to give the reader an overview of the recent findings concerning the biology of IL-21 and its physiological role in immunity, infection, and cancer.

摘要

白细胞介素-21是I型细胞因子家族中最新发现的成员。在结构上，IL-21与IL-2、IL-4和IL-15蛋白具有同源性。IL-21与其他三种细胞因子共享共同的γ链，但此外，它还与独特的IL-21Rα链结合，并激活JAK/STAT信号通路。IL-21主要由活化的T细胞产生，但作用于免疫系统中广泛的淋巴细胞和髓细胞，因此能够调节先天性和获得性免疫反应。本综述旨在让读者了解有关IL-21生物学及其在免疫、感染和癌症中的生理作用的最新研究结果。