Kim Y G, Yang K H, Gang S J, Kim B K, Kim S M
Department of Clinical Pathology, Catholic University Medical College, Seoul, Korea.
J Korean Med Sci. 1991 Jun;6(2):165-71. doi: 10.3346/jkms.1991.6.2.165.
We describe a case of solitary myeloma showing cystic change filled with massive crystalline structures in a 54-year-old woman. A bone X-ray showed a solitary cystic osteolytic lesion in the right iliac bone. Serum and urine protein electrophoresis showed no demonstrable M-protein, and bone-marrow aspirates did not show any myeloma cells. Histologic examination of the tumor revealed aggregation of plasma cells with massive extracellular infiltration of the rhomboid-shaped crystalline structures. In immunoperoxidase staining, both these crystalline structures and the cytoplasms of the myeloma cells demonstrated a positive reaction for lambda light chain. By electron microscope, the large extracellular crystalline structures were observed, and we found unique rhomboid or rectangular-shaped crystalline structures in the cytoplasms of the myeloma cells.
我们描述了一例54岁女性的孤立性骨髓瘤病例，其出现充满大量晶体结构的囊性改变。骨X线显示右髂骨有一个孤立性囊性溶骨性病变。血清和尿蛋白电泳未显示出可检测到的M蛋白，骨髓穿刺未发现任何骨髓瘤细胞。肿瘤的组织学检查显示浆细胞聚集，伴有大量菱形晶体结构的细胞外浸润。在免疫过氧化物酶染色中，这些晶体结构和骨髓瘤细胞的细胞质对λ轻链均呈阳性反应。通过电子显微镜观察到大量细胞外晶体结构，并且在骨髓瘤细胞的细胞质中发现了独特的菱形或矩形晶体结构。
