Gilman S C, Colton J S, Grossman Y
Diving Medicine Department, Naval Medical Research Institute, Bethesda, Md.
J Neural Transm Gen Sect. 1991;86(1):1-9. doi: 10.1007/BF01250371.
Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on 45Ca2+ uptake and [3H]GABA release using a calcium ionophore A 23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [3H]GABA, while having no significant effect on A 23187-stimulated 45Ca2+ uptake. On the other hand, both depolarization-induced 45Ca2+ uptake and [3H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.
使用豚鼠大脑皮质突触体标本，通过钙离子载体A 23187（其绕过电压敏感性钙通道）来研究62个绝对大气压的压力对45Ca2+摄取和[3H]GABA释放的影响。结果发现，压力对A 23187诱导的[3H]GABA释放具有抑制作用，而对A 23187刺激的45Ca2+摄取无显著影响。另一方面，压力暴露会抑制去极化诱导的45Ca2+摄取和[3H]GABA释放。这些结果表明，压力可能通过影响钙内流后的突触前事件来抑制GABA释放。
Zotero 插件