牛磺酸对豚鼠压力诱导震颤的拮抗作用。
Antagonism by taurine of pressure-induced tremor in the guinea pig.
作者信息
Gilman S C, Hallenbeck J M, Ackerman M J, Bradley M E
出版信息
J Appl Physiol Respir Environ Exerc Physiol. 1984 Nov;57(5):1409-11. doi: 10.1152/jappl.1984.57.5.1409.
PMID:6520033
Abstract
The tremorogenic effect of high pressure was antagonized in guinea pigs by intravenous treatment with taurine in doses of 250 and 500 mg/kg. Also pretreatment with 250 mg/kg taurine suppressed tremor development as evidenced by increased threshold and decreased amplitude. It is hypothesized that antagonism of pressure-induced tremor by taurine may be related to changes in membrane calcium transport.
摘要
通过静脉注射250和500毫克/千克剂量的牛磺酸，可拮抗豚鼠中高压的致颤效应。此外，用250毫克/千克牛磺酸进行预处理可抑制震颤的发展，这表现为阈值升高和振幅降低。据推测，牛磺酸对压力诱导震颤的拮抗作用可能与膜钙转运的变化有关。
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