对“γ-TuRC蛋白在纺锤体组装检查点中的中心体非依赖性作用”的评论
Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".
作者信息
Weaver Beth A A, Cleveland Don W
机构信息
Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0670, USA.
出版信息
Science. 2007 May 18;316(5827):982; author reply 982. doi: 10.1126/science.1139523.
Müller et al. (Reports, 27 October 2006, p. 654) proposed a role for microtubule nucleation in mitotic checkpoint signaling. However, their observations of spindle defects and mitotic delay after depletion of gamma-tubulin ring complex (gamma-TuRC) components are fully consistent with activation of the established pathway of checkpoint signaling in response to incomplete or unstable interactions between kinetochores of mitotic chromosomes and spindle microtubules.
米勒等人（《报告》，2006年10月27日，第654页）提出微管成核在有丝分裂检查点信号传导中起作用。然而，他们观察到γ-微管蛋白环复合物（γ-TuRC）成分耗尽后出现纺锤体缺陷和有丝分裂延迟，这与因有丝分裂染色体动粒与纺锤体微管之间相互作用不完全或不稳定而激活已确立的检查点信号传导途径完全一致。
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