关于“γ-微管蛋白环形复合物蛋白在纺锤体组装检查点中的非中心体依赖性作用”的评论
Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".
作者信息
Taylor Stephen S, Hardwick Kevin G, Sawin Kenneth E, Biggins Sue, Piatti Simonetta, Khodjakov Alexey, Rieder Conly L, Salmon Edward D, Musacchio Andrea
机构信息
Faculty of Life Sciences, University of Manchester, Manchester, UK.
出版信息
Science. 2007 May 18;316(5827):982; author reply 982. doi: 10.1126/science.1139484.
Abstract
Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.
摘要
米勒等人（《报告》，2006年10月27日，第654页）表明，对γ-微管蛋白环复合物（γ-TuRC）的抑制会激活纺锤体组装检查点（SAC），这使他们认为γ-TuRC蛋白在SAC激活中发挥分子作用。由于γ-TuRC抑制会导致多效性纺锤体缺陷，而众所周知这种缺陷会激活动粒衍生的检查点信号，我们认为这一结论为时过早。
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本文引用的文献
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A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint.γ-微管蛋白环复合物蛋白在纺锤体组装检查点中的非中心体依赖性作用。
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Making microtubules and mitotic spindles in cells without functional centrosomes.在没有功能性中心体的细胞中制造微管和有丝分裂纺锤体。
Curr Biol. 2006 Mar 21;16(6):564-9. doi: 10.1016/j.cub.2006.01.053.
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GCP-WD is a gamma-tubulin targeting factor required for centrosomal and chromatin-mediated microtubule nucleation.GCP-WD是中心体和染色质介导的微管成核所必需的一种γ-微管蛋白靶向因子。
Nat Cell Biol. 2006 Feb;8(2):137-47. doi: 10.1038/ncb1349. Epub 2005 Dec 25.
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The Drosophila gamma-tubulin small complex subunit Dgrip84 is required for structural and functional integrity of the spindle apparatus.果蝇γ-微管蛋白小复合体亚基Dgrip84是纺锤体结构和功能完整性所必需的。
Mol Biol Cell. 2006 Jan;17(1):272-82. doi: 10.1091/mbc.e05-08-0722. Epub 2005 Oct 19.
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Elongation of centriolar microtubule triplets contributes to the formation of the mitotic spindle in gamma-tubulin-depleted cells.中心粒微管三联体的延长有助于γ-微管蛋白缺失细胞中有丝分裂纺锤体的形成。
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