Taylor Stephen S, Hardwick Kevin G, Sawin Kenneth E, Biggins Sue, Piatti Simonetta, Khodjakov Alexey, Rieder Conly L, Salmon Edward D, Musacchio Andrea
Faculty of Life Sciences, University of Manchester, Manchester, UK.
Science. 2007 May 18;316(5827):982; author reply 982. doi: 10.1126/science.1139484.
Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.
米勒等人（《报告》，2006年10月27日，第654页）表明，对γ-微管蛋白环复合物（γ-TuRC）的抑制会激活纺锤体组装检查点（SAC），这使他们认为γ-TuRC蛋白在SAC激活中发挥分子作用。由于γ-TuRC抑制会导致多效性纺锤体缺陷，而众所周知这种缺陷会激活动粒衍生的检查点信号，我们认为这一结论为时过早。
