Toda Masahiro, Kusakabe Shinsuke, Nagasawa Shingo, Kitamura Kazuyuki, Morimoto Kanehisa
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Biomed Res. 2007 Apr;28(2):115-8. doi: 10.2220/biomedres.28.115.
We investigated the effect of laughter on salivary endocrinological stress marker chromogranin A (CgA). In saliva samples collected from 11 healthy males before and after watching a comic film or a non-humorous control film, salivary CgA levels were determined by enzyme-linked immunosorbent assay (ELISA). Samples taken after watching the comic film showed increased levels of CgA. This tendency was more pronounced in individuals with lower initial levels of stress. The control samples showed no significant change in CgA levels. Stress score, subjectively evaluated using a visual analog scale, decreased significantly after watching the comic film. These findings suggest that, in addition to a stress relief effect, laughter can bring about feeling uplifted or fulfilled.
我们研究了笑对唾液内分泌应激标志物嗜铬粒蛋白A（CgA）的影响。在11名健康男性观看喜剧电影或非幽默对照电影前后采集的唾液样本中，通过酶联免疫吸附测定（ELISA）法测定唾液CgA水平。观看喜剧电影后采集的样本显示CgA水平升高。这种趋势在初始应激水平较低的个体中更为明显。对照样本的CgA水平没有显著变化。使用视觉模拟量表主观评估的应激评分在观看喜剧电影后显著降低。这些发现表明，除了缓解压力的作用外，笑还能带来振奋或满足的感觉。
