Chiba Yu, Saitoh Shigeyuki, Takagi Satoru, Ohnishi Hirofumi, Katoh Nobuo, Ohata Junichi, Nakagawa Motoya, Shimamoto Kazuaki
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan.
Hypertens Res. 2007 Mar;30(3):229-36. doi: 10.1291/hypres.30.229.
We assessed the amount of visceral fat using ultrasonography (US) and studied its relationship to cardiovascular disease risk factors, particularly blood pressure. The subjects in the first study were 45 male and 61 female outpatients. We measured the visceral fat area (VFA) of each subject using abdominal CT and waist circumference (WC), and visceral fat distance (VFD) using US. The subjects in the second study were 353 male and 457 female inhabitants of a rural community, for whom VFD and WC were measured. We divided subjects into tertiles based on VFD and WC, and studied the relationship between each group and individual risk factors. In an analysis of outpatient subjects, the correlation coefficient between VFA and VFD was satisfactory: r=0.660 for men and r=0.643 for women. In the analysis of the rural subjects, the high VFD group had a significantly higher odds ratio than the low VFD group in high blood pressure (HBP) and hypertriglyceridemia (HTG) for men and in HBP, HTG and low high-density lipoprotein cholesterolemia (LHDL) for women. Moreover, adjusting VFD for body mass index revealed that, in comparison to WC, VFD was significantly related to risk factors. VFD was used as an independent variable in multiple regression analysis with blood pressure level as a dependent variable; no significant association between WC and blood pressure was obtained. Visceral fat assessment by US may be useful for epidemiological study and for clinics with no abdominal CT equipment for identifying high-risk individuals, such as those with metabolic syndrome.
我们使用超声检查（US）评估内脏脂肪量，并研究其与心血管疾病危险因素，尤其是血压的关系。第一项研究的受试者为45名男性和61名女性门诊患者。我们使用腹部CT测量了每位受试者的内脏脂肪面积（VFA）和腰围（WC），并使用超声测量了内脏脂肪距离（VFD）。第二项研究的受试者为一个农村社区的353名男性和457名女性居民，测量了他们的VFD和WC。我们根据VFD和WC将受试者分为三分位数，并研究了每组与个体危险因素之间的关系。在对门诊受试者的分析中，VFA与VFD之间的相关系数令人满意：男性r=0.660，女性r=0.643。在对农村受试者的分析中，高VFD组在男性高血压（HBP）和高甘油三酯血症（HTG）以及女性HBP、HTG和低高密度脂蛋白胆固醇血症（LHDL）方面的优势比显著高于低VFD组。此外，对VFD进行体重指数调整后发现，与WC相比，VFD与危险因素显著相关。在以血压水平为因变量的多元回归分析中，VFD被用作自变量；未获得WC与血压之间的显著关联。通过超声评估内脏脂肪可能有助于流行病学研究，对于没有腹部CT设备的诊所来说，也有助于识别高危个体，如患有代谢综合征的个体。
