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韩国女性的乳腺癌筛查必须考虑传统风险以及两个遗传风险因素:基因多态性和可遗传基因突变。

Breast cancer screening for Korean women must consider traditional risks as well as two genetic risk factors: genetic polymorphisms and inheritable gene mutations.

作者信息

Anderson Gwen, Jun Myunghee, Choi Kyungsook

机构信息

School of Nursing, San Diego State University, San Diego, CA 91962, USA.

出版信息

Cancer Nurs. 2007 May-Jun;30(3):213-22. doi: 10.1097/01.NCC.0000270705.41919.dc.

Abstract

Asian women worldwide have increasing rates of breast cancer due to acculturation which may be altering, gene to gene and/or, genetic and environmental interactions at the cellular level. The purpose of this integrative review is to alert nurses and physicians to rising rates of breast cancer among Korean women and to a need for breast health screening programs in the United States that are more culturally responsive and attentive to the effects of acculturation and genetic risk factors. A comprehensive review of the English and Korean literature pertaining to rising incidence of breast cancer among Korean women in their homeland and in the United States is retraced since 1983. Korean women in Korea and in the United States face similar barriers to cancer screening services. Korean women need knowledge about the effect of acculturation on breast cancer risk and patterns of familial inheritance of breast cancer. Screening is especially important among younger women (younger than age 35), those with a strong family history, and women in community settings where acculturation has its greatest impact. Nurse clinicians and researchers who aim to improve breast cancer screening among minority women must pay closer attention to these risk factors and design culturally competent services and evaluation research. In the United States and Korea, Korean nurses are needed to specialize in breast cancer screening as well as cancer genetic risk assessment and genetic counseling.

摘要

由于文化适应,全球范围内的亚洲女性患乳腺癌的几率不断上升,这种文化适应可能正在改变细胞水平上基因与基因之间和/或基因与环境之间的相互作用。本综合综述的目的是提醒护士和医生注意韩国女性乳腺癌发病率的上升,以及美国需要建立更具文化适应性、更关注文化适应影响和遗传风险因素的乳房健康筛查项目。自1983年以来,对有关韩国本土及美国的韩国女性乳腺癌发病率上升的英文和韩文文献进行了全面回顾。韩国国内和美国的韩国女性在癌症筛查服务方面面临类似的障碍。韩国女性需要了解文化适应对乳腺癌风险的影响以及乳腺癌家族遗传模式。筛查对于年轻女性(35岁以下)、有强烈家族病史的女性以及文化适应影响最大的社区环境中的女性尤为重要。旨在改善少数族裔女性乳腺癌筛查的护士临床医生和研究人员必须更加关注这些风险因素,并设计具有文化胜任力的服务和评估研究。在美国和韩国,需要韩国护士专门从事乳腺癌筛查以及癌症遗传风险评估和遗传咨询工作。

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